12,185 research outputs found
Vibration suppression for monopile and spar-buoy offshore wind turbines using the structure-immittance approach
Offshore wind turbines have the potential to capture the high-quality wind resource. However, the significant wind and wave excitations may result in excessive vibrations and decreased reliability. To reduce vibrations, passive structural control devices, such as the tuned mass damper (TMD), have been used. To further enhance the vibration suppression capability, inerter-based absorbers (IBAs) have been studied using the structure-based approach, that is, proposing specific stiffness-damping-inertance elements layouts for investigation. Such an approach has a critical limitation of being only able to cover specific IBA layouts, leaving numerous beneficial configurations not identified. This paper adopts the newly introduced structure-immittance approach, which is able to cover all network layout possibilities with a predetermined number of elements. Linear monopile and spar-buoy turbine models are first established for optimisation. Results show that the performance improvements can be up to 6.5% and 7.3% with four and six elements, respectively, compared with the TMD. Moreover, a complete set of beneficial IBA layouts with explicit element types and numbers have been obtained, which is essential for next-step real-life applications. In order to verify the effectiveness of the identified absorbers with OpenFAST, an approach has been established to integrate any IBA transfer functions. It has been shown that the performance benefits preserve under both the fatigue limit state (FLS) and the ultimate limit state (ULS). Furthermore, results show that the mass component of the optimum IBAs can be reduced by up to 25.1% (7,486βkg) to achieve the same performance as the TMD
Substrate-induced band gap opening in epitaxial graphene
Graphene has shown great application potentials as the host material for next
generation electronic devices. However, despite its intriguing properties, one
of the biggest hurdles for graphene to be useful as an electronic material is
its lacking of an energy gap in the electronic spectra. This, for example,
prevents the use of graphene in making transistors. Although several proposals
have been made to open a gap in graphene's electronic spectra, they all require
complex engineering of the graphene layer. Here we show that when graphene is
epitaxially grown on the SiC substrate, a gap of ~ 0.26 is produced. This gap
decreases as the sample thickness increases and eventually approaches zero when
the number of layers exceeds four. We propose that the origin of this gap is
the breaking of sublattice symmetry owing to the graphene-substrate
interaction. We believe our results highlight a promising direction for band
gap engineering of graphene.Comment: 10 pages, 4 figures; updated reference
Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes
Objectives: Circulating Fibroblast Growth Factor 21 (FGF21) levels are increased in insulin resistant states such as obesity, type 2 diabetes mellitus and gestational diabetes mellitus (GDM). In addition, GDM is associated with serious maternal and fetal complications. We sought to study human cerebrospinal fluid (CSF) and corresponding circulating FGF21 levels in women with gestational diabetes mellitus (GDM) and in age and BMI matched control subjects. We also assessed FGF21 secretion from GDM and control human placental explants.
Design: CSF and corresponding plasma FGF21 levels of 24 women were measured by ELISA [12 GDM (age: 26β47 years, BMI: 24.3β36.3 kg/m2) and 12 controls (age: 22β40 years, BMI: 30.1β37.0 kg/m2)]. FGF21 levels in conditioned media were secretion from GDM and control human placental explants were also measured by ELISA.
Results: Glucose, HOMA-IR and circulating NEFA levels were significantly higher in women with GDM compared to control subjects. Plasma FGF21 levels were significantly higher in women with GDM compared to control subjects [234.3 (150.2β352.7) vs. 115.5 (60.5β188.7) pg/ml; P<0.05]. However, there was no significant difference in CSF FGF21 levels in women with GDM compared to control subjects. Interestingly, CSF/Plasma FGF21 ratio was significantly lower in women with GDM compared to control subjects [0.4 (0.3β0.6) vs. 0.8 (0.5β1.6); P<0.05]. FGF21 secretion into conditioned media was significantly lower in human placental explants from women with GDM compared to control subjects (P<0.05).
Conclusions: The central actions of FGF21 in GDM subjects maybe pivotal in the pathogenesis of insulin resistance in GDM subjects. The significance of FGF21 produced by the placenta remains uncharted and maybe crucial in our understanding of the patho-physiology of GDM and its associated maternal and fetal complications. Future research should seek to elucidate these points
Radial Growth of Qilian Juniper on the Northeast Tibetan Plateau and Potential Climate Associations
There is controversy regarding the limiting climatic factor for tree radial growth at the alpine treeline on the northeastern Tibetan Plateau. In this study, we collected 594 increment cores from 331 trees, grouped within four altitude belts spanning the range 3550 to 4020 m.a.s.l. on a single hillside. We have developed four equivalent ring-width chronologies and shown that there are no significant differences in their growth-climate responses during 1956 to 2011 or in their longer-term growth patterns during the period AD 1110β2011. The main climate influence on radial growth is shown to be precipitation variability. Missing ring analysis shows that tree radial growth at the uppermost treeline location is more sensitive to climate variation than that at other elevations, and poor tree radial growth is particularly linked to the occurrence of serious drought events. Hence water limitation, rather than temperature stress, plays the pivotal role in controlling the radial growth of Sabina przewalskii Kom. at the treeline in this region. This finding contradicts any generalisation that tree-ring chronologies from high-elevation treeline environments are mostly indicators of temperature changes
Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to be fully understood. Here, we showed the suppression of both type I and type III IFN signalling by SFTSV NSs protein is mediated through inhibition of STAT1 phosphorylation and activation. Infection with live SFTSV or expression of NSs potently suppressed IFN-stimulated genes but not NFΞΊB activation. NSs was capable of counteracting the activity of IFN-Ξ±1, IFN-Ξ², IFN-Ξ»1 and IFN-Ξ»2. Mechanistically, NSs associated with STAT1 and STAT2, mitigated IFN-Ξ²-induced phosphorylation of STAT1 at S727, and reduced the expression and activity of STAT1 protein in IFN-Ξ²-treated cells, resulting in the inhibition of STAT1 and STAT2 recruitment to IFN-stimulated promoters. Taken together, SFTSV NSs protein is an IFN antagonist that suppresses phosphorylation and activation of STAT1.postprin
Entanglement of single-photons and chiral phonons in atomically thin WSe
Quantum entanglement is a fundamental phenomenon which, on the one hand,
reveals deep connections between quantum mechanics, gravity and the space-time;
on the other hand, has practical applications as a key resource in quantum
information processing. While it is routinely achieved in photon-atom
ensembles, entanglement involving the solid-state or macroscopic objects
remains challenging albeit promising for both fundamental physics and
technological applications. Here, we report entanglement between collective,
chiral vibrations in two-dimensional (2D) WSe host --- chiral phonons (CPs)
--- and single-photons emitted from quantum dots (QDs) present in it. CPs which
carry angular momentum were recently observed in WSe and are a
distinguishing feature of the underlying honeycomb lattice. The entanglement
results from a "which-way" scattering process, involving an optical excitation
in a QD and doubly-degenerate CPs, which takes place via two indistinguishable
paths. Our unveiling of entanglement involving a macroscopic, collective
excitation together with strong interaction between CPs and QDs in 2D materials
opens up ways for phonon-driven entanglement of QDs and engineering chiral or
non-reciprocal interactions at the single-photon level
Lineage Divergence and Historical Gene Flow in the Chinese Horseshoe Bat (Rhinolophus sinicus)
PMCID: PMC3581519This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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